Crucial role of Glutathione as the body’s Master Antioxidant

Crucial role of Glutathione as the body’s Master AntioxidantAntioxidants play a very important role in maintaining our good health. Our body’s master antioxidant is Glutathione which protects the living cells from all the free radicals and toxins that enter into our body through the environmental pollutants present in the water we drink, the food we eat and even the air that we breathe in.Glutathione is made up of three protein building blocks, called amino acids (glutamic acid, cysteine and glycine). It is produced by every living cell of our body. It is not only the body’s master antioxidant but is also the body’s immune booster and detoxifier.The cells of our body produce glutathione so that it can protect all the living cells of the body from the harm caused by the free radicals. The presence of sufficient amount of glutathione in the body is very essential, especially in the organs like liver and brain, so that the different diseases do not develop.Being the body’s master antioxidant, glutathione reduces the free radicals present in our body and also prevents the destruction and the deterioration of the living cells caused by them. If there is a glutathione deficiency in the body different problems like stress, tremor, sleeplessness, loss of memory etc. start to develop.Glutathione levels may drop in the body due to various reasons like increasing age or development of certain diseases. MaxGXL helps to increase the glutathione level in the body by helping the body cells to increase the glutathione production on an average of 200%.MaxGXL is the only glutathione nutraceutical that can be quantified and verified. MaxGXL has the components of glutathione that cause the body to produce it. MaxGXL is not glutathione itself, as ingesting glutathione will not yield any results, it will just be flushed from the body.

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Free radiclas

Free radicals lead to development and progression of many brain disorders like brain injury, neurodegenerative diseases etc. Glutathione being the brain's master antioxidant plays an important role in protecting the brain from these free radicals and the harm caused by them.

Studies have shown that among all the organs present in our body, our brain is most vulnerable to attack of free radicals as it generates more oxidative by-products than any other organ in the body. Glutathione deficiency in the brain leads to the progression of many neurological and psychiatric diseases caused by these free radicals.

Generation of reactive free radicals and oxidative damage are the main causes responsible for death of brain cells due to brain injury. Presence of good levels of glutathione in the brain prevents the death of cells from brain injury.

Studies have suggested that, the cells in males and females react in different ways to the brain injuries. After a brain injury, the glutathione level was found to remain constant in the case of females but was found to drop by 80% in case of males with the same brain injury.

The death rate of brain cells become faster when there is depletion in the glutathione level. Therefore, it is suggested that the males with a brain injury will be subjected to shorter survival period compared to females with the same brain injury.

Improved glutathione level can help patients with brain injuries to prevent death of brain cells and also help to improve the longevity.

MaxGXl will help the body to manufacture on the average of 200% more glutathione, which helps the brain cells to rebuild themselves much more quickly.

Research scientists at the Buck Institute have discovered that mice with less of the natural antioxidant glutathione,

NaturalNews) Research scientists at the Buck Institute have discovered that mice with less of the natural antioxidant glutathione, particularly in their dopamine-producing neurons, become crippled by nerve damage. In fact, the mice developed symptoms that match up very well with Parkinson’s disease in human beings. In order to perform the experiment, scientists first created mice that could be triggered chemically to greatly reduce the amount of glutathione in their dopamine-creating neurons, which then resulted in the Parkinson-like symptoms.

This new discovery might call into question the current pharmaceutical approach to Parkinson's Disease; which doses patients with dopamine equivalents, or with drugs that boost dopamine's effect (as a former prescription drug, Methamphetamine, or “Crystal Meth” does). Unfortunately, these Parkinson's drugs also have been found to cause many of the effects that are also seen with Methamphetamine, such as gambling and other impulse-control problems. Now it seems that the underlying problem may not really be dopamine.

Antioxidants keep our cells clean by combining with and eliminating very dangerous reactive molecules that can cause random changes in proteins, resulting in cancer, heart disease or other chronic illnesses. Those random changes are often referred to as “oxidative stress” and cause inflammation as well. This new research shows that natural antioxidants are important in maintaining nerve cell function, too.

The good news is that you can boost your levels of natural antioxidants rather easily without prescription drugs in several ways. So if this new research holds up, by boosting your natural levels of antioxidants, you may be protecting yourself against Parkinson's Disease as well as cancer, infection, and much more.

Glutathione is probably the second most important antioxidant that our bodies make - melatonin is the most important, and by far the least costly to make use of, energetically. Vitamin C would come in third. Consistent sleep in true darkness is the best prescription to boost your melatonin; but of course, supplements of melatonin are also widely sold. Doses much less than the standard 3mg are now recommended however, since too much melatonin can slop over into daytime and confuse your clock and immune system. As well, it has been suggested that taking melatonin supplements may cause a decline in your own natural production of this critical antioxidant and night-time hormone.

A relatively new and easy approach to increasing melatonin production naturally, based on recent chronobiological research is to wear orange-tinted glasses (low blue light eyewear) for an hour or two in the morning and at night. By cutting out exposure to blue light, our bodies think it's night, and begin to produce melatonin. Since about ten hours of darkness (or low blue light) in which to produce melatonin are ideal, blocking blue light means more of the critical antioxidant melatonin, for better health. Experiments by researchers at the Lighting Innovations Institute of John Carroll University have shown this approach to be effective for fertility, depression, bipolar disorder, and other medical problems.

Many antioxidant food and nutritional supplements, such as lipoic acid, wolfberries (goji berries) and pomegranates have also been shown to have beneficial effects on health, by reducing oxidative stress and inflammation.

We all have plenty of glutathione in each of our cells, however most of it isn't charged up and ready for use at any given moment - in fact a standard medical measure of “oxidative stress” is whether at least ten percent of the glutathione in our cells is charged up and ready to be used, if needed. Glutathione isn't usually recommended as a nutritional supplement itself because it isn't easily absorbed by the gut. However its “precursor”, the amino acid cysteine, is available.

For most of us in the modern world, the likely reason for having insufficient glutathione in the active form is that we aren't getting enough melatonin at night. Better sleep hygiene and more darkness, as well as more regular bedtimes, are a great way to start. Food or supplements rich in natural antioxidants are also valuable - and you can start today.

I found this article at the link below.

http://www.naturalnews.com/022609.html

Role of glutathione in cellular resistance to alkylating agents

Both elevated glutathione levels and increased activity of the enzyme glutathione S-transferase have been associated with the resistance of cells to alkylating agents.

We have demonstrated that one mechanism of this resistance is the inactivation of the alkylating agents by conjugation with glutathione.

This conjugation can be catalyzed by glutathione S-transferase. For the nitrogen mustard agents we have studied, both the spontaneous and enzyme catalyzed reactions proceed through the aziridinium intermediates of the alkylating agents, and the [alpha] isoenzymes of GST are involved.

In a study of cyclophosphamide resistant medulloblastoma cell lines elevated cellular concentrations of glutathione correlated well with the resistance of the cell lines.

by: Michael O Colvin, Henry S Friedman, Michael P Gamcsik, Catherine Fenselau, John Hilton
Advances in Enzyme Regulation, Vol. 33 (1993), pp. 19-26

Glutathione more information

Glutathione is produced by the cells of our body. It is the natural antioxidant which is most abundantly present in our body. Glutathione, also known as GSH, is responsible for the protection of our vision, boosting our immune system, turning carbohydrates into energy and preventing the building up of oxidized fats that may cause atherosclerosis.

Glutathione is composed of three amino acids: cysteine, glutamic acid and glycine. Although glutathione is found in every part of our body, it is mainly found in the lungs, liver and the intestinal track. Largest amount of glutathione is produced and stored in the liver as there it is used to detoxify harmful compounds so that they can be flushed out of the body easily. The red and the white blood cells in the bloodstream receive supplies of glutathione directly from the lever. Due to this the blood cells remain healthy and strengthen the immune system. Besides all these, glutathione is also known to have an anti-aging affect on the body.

With the increasing age, the glutathione levels in the body decreases. Due to lack of glutathione the immune system weakens and thus the body becomes prone to illnesses. Energy level also comes down. Low levels of glutathione have a destructive effect on the nervous system also. Therefore to avoid any illness it is necessary to increase the production of glutathione in the body.

Glutathione if taken orally does not get absorbed by the body. MAXGXL Glutathione accelerator helps to accelerate the production of glutathione in our body naturally. Therefore, MAXGXL helps to increase the energy levels and also helps to strengthen the immune system of our body.

Glutathione used for Parkinsons, Austism and Schizophrenia

DR. WEEKS’  COMMENT:   Glutathione, optimally given intravenously (IV),  is very beneficial for a number of degenerative illnesses such as MS, ALS,  Parkinson’s, Autism and Schizophrenia.  If your doctor won’t give you IV glutathione,  ask him or her to call us here at the Weeks Clinic for more scientific support. 

We now offer an oral version which is liposomally stabilized glutathione. While not as  potent as the IV version, it is very many of our patients concerned with protecting cognitive function (memory etc.) as well as for protecting cardiac function.

More infromation on this article.

http://weeksmd.com/?p=458

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